STEP 1 and 2 proteomics: semaglutide treatment effect
Show the top 1000 protein biomarkers only.
Select a candidate protein biomarker (gene symbol; seqID; protein name) from the list below (red circle in plot):
Adjust model for weight and HbA1c change at end of trial.
The Holm-Bonferroni (HB) method was used to assess statistical significance. A P value threshold of 0.05 was used for statistical significance.
Select a protein set from the list below (orange points in plot):
Alanine_Transaminase_down
Alanine_Transaminase_up
Alcohol_Dependence_down
Alcohol_Dependence_up
Asthma_down
Asthma_up
Atherosclerotic_disease_Myocardial_Infarction_vs_no_Myocardial_Infarction_down
Atherosclerotic_disease_Myocardial_Infarction_vs_no_Myocardial_Infarction_up
Autoimmune_Disease_down
Autoimmune_Disease_up
Bipolar_Disorder_down
Bipolar_Disorder_up
BMI_max_down
BMI_max_up
Breast_Cancer_down
Breast_Cancer_up
C_Reactive_Protein_down
C_Reactive_Protein_up
Chronic_Lymphocytic_Leukemia_and_Small_Lymphocytic_Lymphoma_down
Chronic_Lymphocytic_Leukemia_and_Small_Lymphocytic_Lymphoma_up
Cigarettes_per_day_down
Cigarettes_per_day_up
Depression_down
Depression_up
Echo_Ejection_Fraction_reduced_down
Echo_Ejection_Fraction_reduced_up
Fibromyalgia_down
Fibromyalgia_up
HbA1c_down
HbA1c_up
Hypertension_medication_4ormoresimultaneousdrugs_vs_onedrugonly_down
Hypertension_medication_4ormoresimultaneousdrugs_vs_onedrugonly_up
Invasive_bacteria_down
Invasive_bacteria_up
Neuropathic_Pain_down
Neuropathic_Pain_up
Nicotine_dependence_vs_low_Quantity_Smokers_down
Nicotine_dependence_vs_low_Quantity_Smokers_up
None
Psoriasis_down
Psoriasis_up
Rehab_admission_down
Rehab_admission_up
Sleep_Apnea_Severe_Moderate_down
Sleep_Apnea_Severe_Moderate_up
Sleep_Insomnia_down
Sleep_Insomnia_up
The protein sets were derived based on the deCODE cohort including almost 35K participants, and the 5K version of the SomaScan assay.
As an example, many of the proteins in the set "BMI_max_down" (those that decrease with higher BMI in deCODE) are increased by treatment with semaglutide in STEP, as expected.
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